Wenge Guo

Wenge Guo
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Wenge Guo

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Pub Categories

Mathematics - Statistics (8)
Statistics - Theory (8)
Statistics - Methodology (7)
Physics - Atomic Physics (2)
Quantum Physics (2)
Physics - Optics (1)
Statistics - Applications (1)

Publications Authored By Wenge Guo

When dealing with the problem of simultaneously testing a large number of null hypotheses, a natural testing strategy is to first reduce the number of tested hypotheses by some selection (screening or filtering) process, and then to simultaneously test the selected hypotheses. The main advantage of this strategy is to greatly reduce the severe effect of high dimensions. However, the first screening or selection stage must be properly accounted for in order to maintain some type of error control. Read More

Complex large-scale studies, such as those related to microarray data and fMRI studies, often involve testing multiple hierarchically ordered hypotheses. However, most existing false discovery rate (FDR) controlling procedures do not exploit the inherent hierarchical structure among the tested hypotheses. In this paper, we first present a generalized stepwise procedure which generalizes the usual stepwise procedure to the case where each hypothesis is tested with a different set of critical constants. Read More

Controlling the false discovery rate (FDR) is a powerful approach to multiple testing. In many applications, the tested hypotheses have an inherent hierarchical structure. In this paper, we focus on the fixed sequence structure where the testing order of the hypotheses has been strictly specified in advance. Read More

In complex clinical trials, multiple research objectives are often grouped into sets of objectives based on their inherent hierarchical relationships. Consequently, the hypotheses formulated to address these objectives are grouped into ordered families of hypotheses and thus to be tested in a pre-defined sequence. In this paper, we introduce a novel Bonferroni based multiple testing procedure for testing hierarchically ordered families of hypotheses. Read More

Often in multiple testing, the hypotheses appear in non-overlapping blocks with the associated $p$-values exhibiting dependence within but not between blocks. We consider adapting the Benjamini-Hochberg method for controlling the false discovery rate (FDR) and the Bonferroni method for controlling the familywise error rate (FWER) to such dependence structure without losing their ultimate controls over the FDR and FWER, respectively, in a non-asymptotic setting. We present variants of conventional adaptive Benjamini-Hochberg and Bonferroni methods with proofs of their respective controls over the FDR and FWER. Read More

In this paper, the problem of error control of stepwise multiple testing procedures is considered. For two-sided hypotheses, control of both type 1 and type 3 (or directional) errors is required, and thus mixed directional familywise error rate control and mixed directional false discovery rate control are each considered by incorporating both types of errors in the error rate. Mixed directional familywise error rate control of stepwise methods in multiple testing has proven to be a challenging problem, as demonstrated in Shaffer (1980). Read More

In this paper, we consider the problem of simultaneously testing many two-sided hypotheses when rejections of null hypotheses are accompanied by claims of the direction of the alternative. The fundamental goal is to construct methods that control the mixed directional familywise error rate, which is the probability of making any type 1 or type 3 (directional) error. In particular, attention is focused on cases where the hypotheses are ordered as $H_1 , \ldots, H_n$, so that $H_{i+1}$ is tested only if $H_1 , \ldots, H_i$ have all been previously rejected. Read More

The probability of false discovery proportion (FDP) exceeding $\gamma\in[0,1)$, defined as $\gamma$-FDP, has received much attention as a measure of false discoveries in multiple testing. Although this measure has received acceptance due to its relevance under dependency, not much progress has been made yet advancing its theory under such dependency in a nonasymptotic setting, which motivates our research in this article. We provide a larger class of procedures containing the stepup analog of, and hence more powerful than, the stepdown procedure in Lehmann and Romano [Ann. Read More

We propose a scheme to implement the Deutsch's algorithm through non-degenerate four-wave mixing process. By employing photon topological charges of optical vortices, we demonstrate the ability to realize the necessary four logic gates for all balanced and constant functions. We also analyze the feasibility of the proposed scheme on the single photon level. Read More

We propose a scheme to distinguish the orbital angular momentum state of the Laguerre-Gaussian (LG) beam based on the electromagnetically induced transparency modulated by a microwave field in atomic ensembles. We show that the transverse phase variation of a probe beam with the LG mode can be mapped into the spatial intensity distribution due to the change of atomic coherence caused by the microwave. The proposal may provide a useful tool for studying higher-dimensional quantum information based on atomic ensembles. Read More

The concept of $k$-FWER has received much attention lately as an appropriate error rate for multiple testing when one seeks to control at least $k$ false rejections, for some fixed $k\ge 1$. A less conservative notion, the $k$-FDR, has been introduced very recently by Sarkar [Ann. Statist. Read More

A classical approach for dealing with the multiple testing problem is to restrict attention to procedures that control the familywise error rate (FWER), the probability of at least one false rejection. In many applications, one might be willing to tolerate more than one false rejection provided the number of such cases is controlled, thereby increasing the ability of the procedure to detect false null hypotheses. This suggests replacing control of the FWER by controlling the probability of $k$ or more false rejections, which is called the $k$-FWER. Read More