Wei Quan Lim

Wei Quan Lim
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Wei Quan Lim

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Physics - Soft Condensed Matter (3)
Computer Science - Data Structures and Algorithms (1)

Publications Authored By Wei Quan Lim

Depletion-induced interactions between colloids in colloid-polymer mixtures depend in range and strength on size, shape, and concentration of depletants. Crowding by colloids in turn affects shapes of polymer coils, such as biopolymers in biological cells. By simulating hard-sphere colloids and random-walk polymers, modeled as fluctuating ellipsoids, we compute depletion-induced potentials and polymer shape distributions. Read More

Depletion forces and macromolecular crowding govern the structure and function of biopolymers in biological cells and the properties of polymer nanocomposite materials. To isolate and analyze the influence of polymer shape fluctuations and penetrability on depletion-induced interactions and crowding by nanoparticles, we model polymers as effective penetrable ellipsoids, whose shapes fluctuate according to the probability distributions of the eigenvalues of the gyration tensor of an ideal random walk. Within this model, we apply Monte Carlo simulation methods to compute the depletion-induced potential of mean force between hard nanospheres and crowding-induced shape distributions of polymers in the protein limit, in which polymer coils can be easily penetrated by smaller nanospheres. Read More

In this paper we look at the problem of scheduling tasks on a single-processor system, where each task requires unit time and must be scheduled within a certain time window, and each task can be added to or removed from the system at any time. On each operation, the system is allowed to reschedule any tasks, but the goal is to minimize the number of rescheduled tasks. Our main result is an allocator that maintains a valid schedule for all tasks in the system if their time windows have constant size and reschedules O(1/{\epsilon}*log(1/{\epsilon})) tasks on each insertion as {\epsilon}->0, where {\epsilon} is a certain measure of the schedule flexibility of the system. Read More

Macromolecular crowding can influence polymer shapes, which is important for understanding the thermodynamic stability of polymer solutions and the structure and function of biopolymers (proteins, RNA, DNA) under confinement. We explore the influence of nanoparticle crowding on polymer shapes via Monte Carlo simulations and free-volume theory of a coarse-grained model of polymer-nanoparticle mixtures. Exploiting the geometry of random walks, we model polymer coils as effective penetrable ellipsoids, whose shapes fluctuate according to the probability distributions of the eigenvalues of the gyration tensor. Read More