Peter Mueller - MPI fuer Radioastronomie, Bonn, Germany

Peter Mueller
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Peter Mueller
MPI fuer Radioastronomie, Bonn, Germany

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Statistics - Applications (6)
Mathematics - Number Theory (6)
Mathematics - Group Theory (5)
Statistics - Methodology (5)
Physics - Soft Condensed Matter (3)
Physics - Statistical Mechanics (3)
Astrophysics (2)
Mathematics - Mathematical Physics (2)
Quantum Physics (2)
Physics - Chemical Physics (2)
Mathematical Physics (2)
Mathematics - Combinatorics (2)
Physics - Atomic Physics (2)
Physics - Disordered Systems and Neural Networks (1)
Physics - Fluid Dynamics (1)
Nuclear Experiment (1)
Physics - Instrumentation and Detectors (1)
Mathematics - Algebraic Geometry (1)
Quantitative Biology - Genomics (1)
Physics - Geophysics (1)

Publications Authored By Peter Mueller

We present a latent feature allocation model to reconstruct tumor subclones subject to phylogenetic evolution that mimics tumor evolution. Similar to most current methods, we consider data from next-generation sequencing. Unlike most methods that use information in short reads mapped to single nucleotide variants (SNVs), we consider subclone reconstruction using pairs of two proximal SNVs that can be mapped by the same short reads. Read More

Tumor cell populations can be thought of as being composed of homogeneous cell subpopulations, with each subpopulation being characterized by overlapping sets of single nucleotide variants (SNVs). Such subpopulations are known as subclones and are an important target for precision medicine. Reconstructing such subclones from next-generation sequencing (NGS) data is one of the major challenges in precision medicine. Read More

We develop novel hierarchical reciprocal graphical models to infer gene networks from heterogeneous data. In the case of data that can be naturally divided into known groups, we propose to connect graphs by introducing a hierarchical prior across group-specific graphs, including a correlation on edge strengths across graphs. Thresholding priors are applied to induce sparsity of the estimated networks. Read More

Targeted therapies on the basis of genomic aberrations analysis of the tumor have shown promising results in cancer prognosis and treatment. Regardless of tumor type, trials that match patients to targeted therapies for their particular genomic aberrations have become a mainstream direction of therapeutic management of patients with cancer. Therefore, finding the subpopulation of patients who can most benefit from an aberration-specific targeted therapy across multiple cancer types is important. Read More

Constructing gene regulatory networks is a fundamental task in systems biology. We introduce a Gaussian reciprocal graphical model for inference about gene regulatory relationships by integrating mRNA gene expression and DNA level information including copy number and methylation. Data integration allows for inference on the directionality of certain regulatory relationships, which would be otherwise indistinguishable due to Markov equivalence. Read More

We study the fluid drift due to a time-dependent dumbbell model of a microswimmer. The model captures important aspects of real microswimmers such as a time-dependent flagellar motion and a no-slip body. The model consists of a rigid sphere for the body and a time-dependent moving Stokeslet representing the flagella. Read More

Background: Octupole-deformed nuclei, such as that of $^{225}$Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015, we reported the first "proof-of-principle" measurement of the $^{225}$Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our $^{225}$Ra EDM measurements by orders of magnitude and evaluates systematic effects that contribute to current and future levels of experimental sensitivity. Read More

We have developed a position response calibration method for a micro-channel plate (MCP) detector with a delay-line anode position readout scheme. Using an {\em in situ} calibration mask, an accuracy of 8~$\mu$m and a resolution of 85~$\mu$m (FWHM) have been achieved for MeV-scale $\alpha$ particles and ions with energies of $\sim$10~keV. At this level of accuracy, the difference between the MCP position responses to high-energy $\alpha$ particles and low-energy ions is significant. Read More

We discuss the use of the determinantal point process (DPP) as a prior for latent structure in biomedical applications, where inference often centers on the interpretation of latent features as biologically or clinically meaningful structure. Typical examples include mixture models, when the terms of the mixture are meant to represent clinically meaningful subpopulations (of patients, genes, etc.). Read More

We propose a Bayesian nonparametric utility-based group sequential design for a randomized clinical trial to compare a gel sealant to standard care for resolving air leaks after pulmonary resection. Clinically, resolving air leaks in the days soon after surgery is highly important, since longer resolution time produces undesirable complications that require extended hospitalization. The problem of comparing treatments is complicated by the fact that the resolution time distributions are skewed and multi-modal, so using means is misleading. Read More

Tumor samples are heterogeneous. They consist of different subclones that are characterized by differences in DNA nucleotide sequences and copy numbers on multiple loci. Heterogeneity can be measured through the identification of the subclonal copy number and sequence at a selected set of loci. Read More

Dynamic treatment regimes in oncology and other disease areas often can be characterized by an alternating sequence of treatments or other actions and transition times between disease states. The sequence of transition states may vary substantially from patient to patient, depending on how the regime plays out, and in practice there often are many possible counterfactual outcome sequences. For evaluating the regimes, the mean final overall time may be expressed as a weighted average of the means of all possible sums of successive transitions times. Read More

We present the first successful 81Kr-Kr radiometric dating of ancient polar ice. Krypton was extracted from the air bubbles in four ~350 kg polar ice samples from Taylor Glacier in the McMurdo Dry Valleys, Antarctica, and dated using Atom Trap Trace Analysis (ATTA). The 81Kr radiometric ages agree with independent age estimates obtained from stratigraphic dating techniques with a mean absolute age offset of 6 +/- 2. Read More

We propose small-variance asymptotic approximations for the inference of tumor heterogeneity (TH) using next-generation sequencing data. Understanding TH is an important and open research problem in biology. The lack of appropriate statistical inference is a critical gap in existing methods that the proposed approach aims to fill. Read More

We have demonstrated that the ion current resulting from collisions between metastable krypton atoms in a magneto-optical trap can be used to precisely measure the trap loading rate. We measured both the ion current of the abundant isotope Kr-83 (isotopic abundance = 11%) and the single-atom counting rate of the rare isotope Kr-85 (isotopic abundance ~ 1x10^-11), and found the two quantities to be proportional at a precision level of 0.9%. Read More

Planar functions over finite fields give rise to finite projective planes and other combinatorial objects. They exist only in odd characteristic, but recently Zhou introduced an even characteristic analogue which has similar applications. In this paper we determine all planar functions on F_q of the form c-->uc^t, where q is a power of 2, t is an integer with 0Read More

Granboulan computed an explicit polynomial whose Galois group over the rational function field Q(t) is the Mathieu group M24. By a result of Malle and Matzat, it was known before that such a polynomial exists. Even more, their proof showed that there is a 1-parameter family of such polynomials. Read More

In this short note we present a simple combinatorial trick which can be effectively applied to show the non--existence of sharply transitive sets of permutations in certain finite permutation groups. Read More

Affiliations: 1MPI fuer Radioastronomie, Bonn, Germany, 2MPI fuer Radioastronomie, Bonn, Germany
Category: Astrophysics

For the first time we have combined dispersion measures and emission measures towards 38 pulsars at KNOWN distances from which we derived the mean electron density in clouds, N_c, and their volume filling factor, F_v, averaged along the line of sight. The emission measures were corrected for absorption by dust and contributions from beyond the pulsar distance. Results: The scale height of the electron layer for our sample is 0. Read More

Ritt studied the functional decomposition of a univariate complex polynomial f into prime (indecomposable) polynomials, f = u_1 o u_2 o ... Read More

We provide an ergodic theorem for certain Banach-space valued functions on structures over $\ZZ^d$, which allow for existence of frequencies of finite patterns. As an application we obtain existence of the integrated density of states for associated finite-range operators in the sense of convergence of the distributions with respect to the supremum norm. These results apply to various examples including periodic operators, percolation models and nearest-neighbour hopping on the set of visible points. Read More

Affiliations: 1MPI fuer Radioastronomie, Bonn, Germany, 2MPI fuer Radioastronomie, Bonn, Germany, 3MPI fuer Radioastronomie, Bonn, Germany
Category: Astrophysics

Combining dispersion measures, distances and emission measures for 157 pulsars lying above \mid b \mid > 5 degree and between 60 degree < l < 360 degree we find the mean volume filling factor (\bar{f_v}) of the diffused ionized gas in the Milky Way. This filling factor is inversely related to the mean electron density (\bar{n_c}) in the clouds, \bar{f_v} = (0.0184 +/- 0. Read More

A transitive permutation group of prime degree is doubly transitive or solvable. We give a direct proof of this theorem by Burnside which uses neither S-ring type arguments, nor representation theory. Read More

In 1923 Schur considered the following problem. Let f(X) be a polynomial with integer coefficients that induces a bijection on the residue fields Z/pZ for infinitely many primes p. His conjecture, that such polynomials are compositions of linear and Dickson polynomials, was proved by M. Read More

We classify the finite primitive permutation groups which have a cyclic subgroup with two orbits. This extends classical topics in permutation group theory, and has arithmetic consequences. By a theorem of C. Read More

Let f(t,X) be an irreducible polynomial over the field of rational functions k(t), where k is a number field. Let O be the ring of integers of k. Hilbert's irreducibility theorem gives infinitely many integral specializations of t to values a in O such that f(a,X) is still irreducible. Read More

Shear relaxation and dynamic density fluctuations are studied within a Rouse model, generalized to include the effects of permanent random crosslinks. We derive an exact correspondence between the static shear viscosity and the resistance of a random resistor network. This relation allows us to compute the static shear viscosity exactly for uncorrelated crosslinks. Read More

A detailed mathematical proof is given that the energy spectrum of a non-relativistic quantum particle in multi-dimensional Euclidean space under the influence of suitable random potentials has almost surely a pure-point component. The result applies in particular to a certain class of zero-mean Gaussian random potentials, which are homogeneous with respect to Euclidean translations. More precisely, for these Gaussian random potentials the spectrum is almost surely only pure point at sufficiently negative energies or, at negative energies, for sufficiently weak disorder. Read More

We investigate the static shear viscosity on the sol side of the vulcanization transition within a minimal mesoscopic model for the Rouse-dynamics of a randomly crosslinked melt of phantom polymers. We derive an exact relation between the viscosity and the resistances measured in a corresponding random resistor network. This enables us to calculate the viscosity exactly for an ensemble of crosslinks without correlations. Read More

Exact results are derived on the averaged dynamics of a class of random quantum-dynamical systems in continuous space. Each member of the class is characterized by a Hamiltonian which is the sum of two parts. While one part is deterministic, time-independent and quadratic, the Weyl-Wigner symbol of the other part is a homogeneous Gaussian random field which is delta correlated in time, but smoothly correlated in position and momentum. Read More

Schroedinger operators with certain Gaussian random potentials in multi-dimensional Euclidean space possess almost surely an absolutely continuous integrated density of states and no absolutely continuous spectrum at sufficiently low energies. Read More